| | | | Sincerely, | |
| | | |
/s/ David P. Meeker, M.D.
David P. Meeker, M.D.
Chairman of the Board, President and Chief Executive Officer |
|
| | | | By Order of the Board of Directors, | |
| | | |
/s/ David P. Meeker, M.D.
David P. Meeker, M.D.
Chairman of the Board, President and Chief Executive Officer April 27, 2021 |
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Name
|
| |
Age
|
| |
Position(s)
|
| |
Class
|
| |
Term
Expires |
|
Stuart A. Arbuckle(1)(2)
|
| |
55
|
| | Director | | |
I
|
| | 2024 | |
Camille L. Bedrosian, M.D.(3)
|
| |
68
|
| | Director | | |
III
|
| | 2023 | |
Todd Foley(1)*
|
| |
49
|
| | Director | | |
II
|
| | 2022 | |
Jennifer Good
|
| |
56
|
| | Director | | |
II
|
| | 2022 | |
Christophe R. Jean(2)
|
| |
65
|
| | Director | | |
I
|
| | 2024 | |
Edward T. Mathers(3)
|
| |
61
|
| | Lead Director | | |
II
|
| | 2022 | |
David W. J. McGirr(2)(3)
|
| |
66
|
| | Director | | |
III
|
| | 2023 | |
David P. Meeker, M.D.
|
| |
66
|
| | Director, Chairman of the Board | | |
III
|
| | 2023 | |
Lynn A. Tetrault, J.D.(1)
|
| |
58
|
| | Director | | |
I
|
| | 2024 | |
Name:
|
| |
Governance and
Nominating Committee |
| |
Compensation
Committee |
| |
Audit
Committee |
| |||||||||
Stuart A. Arbuckle
|
| | | | | | | | | | X | | | | | | X | | |
Camille L. Bedrosian, M.D.
|
| | | | X | | | | | | | | | | | | | | |
Todd Foley#
|
| | | | | | | | | | X | | | | | | | | |
Jennifer Good
|
| | | | | | | | | | | | | | | | | | |
Christophe R. Jean
|
| | | | | | | | | | | | | | | | X | | |
Edward T. Mathers
|
| | | | X* | | | | | | | | | | | | | | |
David W. J. McGirr
|
| | | | X | | | | | | | | | | | | X* | | |
Lynn A. Tetrault, J.D.
|
| | | | | | | | | | X* | | | | | | | | |
Non-Employee Director
|
| |
Annual Fee
|
| |||
Lead Director
|
| | | $ | 25,000 | | |
Non-Executive Chair
|
| | | $ | 30,000 | | |
Chair of the Audit Committee
|
| | | $ | 15,000 | | |
Member of the Audit Committee (other than chair)
|
| | | $ | 7,500 | | |
Chair of the Compensation Committee
|
| | | $ | 12,000 | | |
Member of the Compensation Committee (other than chair)
|
| | | $ | 6,000 | | |
Chair of the Governance and Nominating Committee
|
| | | $ | 8,000 | | |
Member of the Governance and Nominating Committee (other than chair)
|
| | | $ | 4,000 | | |
Non-Employee Director
|
| |
Annual Fee
|
| |||
Lead Director
|
| | | $ | 25,000 | | |
Non-Executive Chair
|
| | | $ | 30,000 | | |
Chair of the Audit Committee
|
| | | $ | 20,000 | | |
Member of the Audit Committee (other than chair)
|
| | | $ | 10,000 | | |
Chair of the Compensation Committee
|
| | | $ | 15,000 | | |
Member of the Compensation Committee (other than chair)
|
| | | $ | 7,500 | | |
Chair of the Governance and Nominating Committee
|
| | | $ | 10,000 | | |
Member of the Governance and Nominating Committee (other than chair)
|
| | | $ | 5,000 | | |
Name
|
| |
Fees earned in
cash ($)(1) |
| |
Option
awards ($)(2) |
| |
Total ($)
|
| |||||||||
Stuart Arbuckle
|
| | | $ | 49,750 | | | | | $ | 235,897 | | | | | $ | 285,647 | | |
Camille Bedrosian, M.D.(3)
|
| | | $ | — | | | | | $ | 654,841 | | | | | $ | 654,841 | | |
Todd Foley
|
| | | $ | 49,000 | | | | | $ | 235,897 | | | | | $ | 284,897 | | |
Jennifer Good
|
| | | $ | 46,000 | | | | | $ | 235,897 | | | | | $ | 281,897 | | |
Christophe R. Jean
|
| | | $ | 47,500 | | | | | $ | 235,897 | | | | | $ | 283,397 | | |
Edward T. Mathers
|
| | | $ | 46,000 | | | | | $ | 235,897 | | | | | $ | 281,897 | | |
David W. J. McGirr
|
| | | $ | 59,000 | | | | | $ | 235,897 | | | | | $ | 294,897 | | |
Lynn A. Tetrault (3)
|
| | | $ | — | | | | | $ | 654,841 | | | | | $ | 654,841 | | |
Name
|
| |
Option Awards
Outstanding |
| |||
Stuart Arbuckle
|
| | | | 48,500 | | |
Camille Bedrosian, M.D.
|
| | | | 37,000 | | |
Todd Foley
|
| | | | 43,500 | | |
Jennifer Good
|
| | | | 48,500 | | |
Christophe R. Jean
|
| | | | 43,500 | | |
Edward T. Mathers
|
| | | | 43,500 | | |
David W. J. McGirr
|
| | | | 130,741 | | |
Lynn A. Tetrault
|
| | | | 37,000 | | |
Name
|
| |
Age
|
| |
Position(s)
|
|
David P. Meeker, M.D.
|
| |
66
|
| | Chairman of the Board, President and Chief Executive Officer | |
Hunter C. Smith
|
| |
53
|
| | Chief Financial Officer and Treasurer | |
Simon Kelner
|
| |
48
|
| | Chief Human Resources Officer | |
Murray Stewart, D.M., F.R.C.P.
|
| |
60
|
| | Chief Medical Officer | |
Jennifer Chien
|
| |
46
|
| | Executive Vice President, Head of North America | |
Yann Mazabraud
|
| |
48
|
| | Executive Vice President, Head of International | |
Name and Principal Position
|
| |
Year
|
| |
Base
Salary(1) ($) |
| |
Bonus
($) |
| |
Stock
Awards (2) |
| |
Option
Awards(2) ($) |
| |
Non-Equity
Incentive Plan Compensation(3) ($) |
| |
All Other
Compensation ($)(4) |
| |
Total
($) |
| ||||||||||||||||||||||||
David P. Meeker, M.D.
President and Chief Executive Officer(5) |
| | | | 2020 | | | | | | 262,308 | | | | | | — | | | | | | 918,500 | | | | | | 12,844,897 | | | | | | 207,958 | | | | | | 43,704 | | | | | | 13,358,867 | | |
Keith M. Gottesdiener, M.D.
Former President and Chief Executive Officer(6) |
| | | | 2020 | | | | | | 142,906 | | | | | | — | | | | | | — | | | | | | 2,810,726 | | | | | | — | | | | | | 495,537 | | | | | | 3,449,169 | | |
| | | 2019 | | | | | | 525,934 | | | | | | — | | | | | | — | | | | | | 4,133,768 | | | | | | 277,340 | | | | | | — | | | | | | 4,937,042 | | | ||
Hunter C. Smith
Chief Financial Officer, Treasurer, Secretary and Former Interim President and Chief Executive Officer(8) |
| | | | 2020 | | | | | | 416,118 | | | | | | 60,000(7) | | | | | | 132,000 | | | | | | 1,837,630 | | | | | | 209,595 | | | | | | 7,125 | | | | | | 2,530,468 | | |
| | | 2019 | | | | | | 396,992 | | | | | | — | | | | | | — | | | | | | 1,286,061 | | | | | | 153,224 | | | | | | 86,576 | | | | | | 1,922,853 | | | ||
Murray Stewart, D.M., F.R.C.P.
Chief Medical Officer |
| | | | 2020 | | | | | | 451,169 | | | | | | 60,000(7) | | | | | | 113,000 | | | | | | 1,555,420 | | | | | | 226,600 | | | | | | 7,125 | | | | | | 2,300,314 | | |
Jennifer Chien
Executive Vice President, Head of North America (9) |
| | | | 2020 | | | | | | 45,577 | | | | | | 100,000(10) | | | | | | 100,000 | | | | | | 1,517,540 | | | | | | 49,375 | | | | | | — | | | | | | 1,712,492 | | |
Nithya Desikan
Former Chief Commercial Officer(11) |
| | | | 2020 | | | | | | 305,510 | | | | | | — | | | | | | 105,000 | | | | | | 1,533,841 | | | | | | — | | | | | | 104,620 | | | | | | 1,943,971 | | |
| | | 2019 | | | | | | 379,063 | | | | | | — | | | | | | — | | | | | | 1,286,061 | | | | | | 145,117 | | | | | | — | | | | | | 1,810,241 | | |
|
Acceleron Pharma
|
| |
Dicerna Pharmaceuticals
|
| |
Odonate Therapeutics
|
|
|
Akebia Therapeutics
|
| |
Esperion Therapeutics
|
| |
Ra Pharmaceuticals
|
|
|
Atara Biotherapeutics
|
| |
Global Blood Therapeutics
|
| |
Reata Pharmaceuticals
|
|
|
Audentes Therapeutics
|
| |
Insmed
|
| |
Syros Pharmaceuticals
|
|
|
Biohaven Pharmaceuticals
|
| |
Intra-Cellular Therapies
|
| |
TG Therapeutics
|
|
|
Cara Therapeutics
|
| |
Iovance Biotherapeutics
|
| |
Zogenix
|
|
|
ChemoCentryx
|
| |
Karyopharm Therapeutics
|
| | | |
|
Deciphera Pharmaceuticals
|
| |
MyoKardia
|
| | | |
Name
|
| |
2019
Base Salary ($) |
| |
2020
Base Salary ($) |
| ||||||
David P. Meeker, M.D.
|
| | | | N/A | | | | | | 620,000 | | |
Keith M. Gottesdiener, M.D.
|
| | | | 530,795 | | | | | | 530,874 | | |
Hunter C. Smith
|
| | | | 399,228 | | | | | | 419,189 | | |
Murray Stewart, D.M., F.R.C.P.
|
| | | | 440,000 | | | | | | 453,200 | | |
Jennifer Chien
|
| | | | N/A | | | | | | 395,000 | | |
Nithya Desikan
|
| | | | 381,888 | | | | | | 400,982 | | |
Name
|
| |
2020 Target Bonus (as
a percentage of base salary) |
| |||
David P. Meeker, M.D.
|
| | | | 60% | | |
Keith M. Gottesdiener, M.D.
|
| | | | 55% | | |
Hunter C. Smith
|
| | | | 40% | | |
Murray Stewart, D.M., F.R.C.P.
|
| | | | 40% | | |
Jennifer Chien
|
| | | | 40% | | |
Nithya Desikan
|
| | | | 40% | | |
Name
|
| |
Shares Subject to
Options |
| |||
Hunter C. Smith
|
| | | | 82,000 | | |
Murray Stewart, D.M., F.R.C.P.
|
| | | | 88,000 | | |
Nithya Desikan
|
| | | | 80,000 | | |
Name
|
| |
Restricted
Stock Units |
| |||
Hunter C. Smith
|
| | | | 25,000 | | |
Murray Stewart, D.M., F.R.C.P.
|
| | | | 25,000 | | |
Nithya Desikan
|
| | | | 25,000 | | |
| | |
Option Awards(1)
|
| |
Stock Awards
|
| ||||||||||||||||||||||||||||||
Name
|
| |
Vesting
Commencement Date(2) |
| |
Number of
Securities Underlying Unexercised Options (#) Exercisable |
| |
Number of
Securities Underlying Unexercised Options (#) Unexercisable |
| |
Option
Exercise Price ($) |
| |
Option
Expiration Date |
| |
Number of
Shares of Units of Stock That Have Not Vested (#) |
| |
Market
Value of Shares or Units of Stock That Have Not Vested ($) (3) |
| |||||||||||||||
David P. Meeker, M.D.
|
| | | | 11/17/2015(4) | | | | | | 43,621 | | | | | | — | | | | | $ | 4.59 | | | | | | 11/16/2025 | | | | | | | | |
| | | | | 2/8/2017(4) | | | | | | 65,430 | | | | | | — | | | | | $ | 6.05 | | | | | | 2/7/2027 | | | | | | | | |
| | | | | 6/6/2018(5) | | | | | | 10,000 | | | | | | — | | | | | $ | 34.89 | | | | | | 6/5/2028 | | | | | | | | |
| | | | | 6/19/2019(5) | | | | | | 15,000 | | | | | | — | | | | | $ | 22.93 | | | | | | 6/18/2029 | | | | | | | | |
| | | | | 6/17/2020(5) | | | | | | — | | | | | | 18,500 | | | | | $ | 21.37 | | | | | | 6/16/2030 | | | | | | | | |
| | | | | 7/17/2020(6) | | | | | | — | | | | | | 900,000 | | | | | $ | 22.53 | | | | | | 7/16/2030 | | | | | | | | |
Keith M. Gottesdiener, M.D.(10)
|
| | | | 7/3/2015(4) | | | | | | 84,208 | | | | | | — | | | | | $ | 4.59 | | | | | | 11/16/2025 | | | | | | | | |
| | | | | 7/3/2015(4) | | | | | | 57,252 | | | | | | — | | | | | $ | 7.52 | | | | | | 12/30/2025 | | | | | | | | |
| | | | | 12/6/2016(4) | | | | | | 201,815 | | | | | | — | | | | | $ | 6.14 | | | | | | 4/4/2027 | | | | | | | | |
| | | | | 2/14/2018(7) | | | | | | 120,312 | | | | | | — | | | | | $ | 25.79 | | | | | | 2/13/2028 | | | | | | | | |
| | | | | 2/13/2019(7) | | | | | | 98,437 | | | | | | — | | | | | $ | 29.78 | | | | | | 2/12/2029 | | | | | | | | |
| | |
Option Awards(1)
|
| |
Stock Awards
|
| ||||||||||||||||||||||||||||||||||||
Name
|
| |
Vesting
Commencement Date(2) |
| |
Number of
Securities Underlying Unexercised Options (#) Exercisable |
| |
Number of
Securities Underlying Unexercised Options (#) Unexercisable |
| |
Option
Exercise Price ($) |
| |
Option
Expiration Date |
| |
Number of
Shares of Units of Stock That Have Not Vested (#) |
| |
Market
Value of Shares or Units of Stock That Have Not Vested ($) (3) |
| |||||||||||||||||||||
Hunter C. Smith
|
| | | | 7/31/2017(6) | | | | | | 142,673 | | | | | | 29,421 | | | | | $ | 6.88 | | | | | | 8/8/2027 | | | | | | | | | | | | | | |
| | | | | 2/14/2018(7) | | | | | | 41,937 | | | | | | 19,063 | | | | | $ | 25.79 | | | | | | 2/13/2028 | | | | | | | | | | | | | | |
| | | | | 2/13/2019(7) | | | | | | 30,625 | | | | | | 39,375 | | | | | $ | 29.78 | | | | | | 2/12/2029 | | | | | | | | | | | | | | |
| | | | | 2/14/2020(7) | | | | | | 15,375 | | | | | | 66,625 | | | | | $ | 17.87 | | | | | | 2/13/2030 | | | | | | | | | | | | | | |
| | | | | 7/17/2020(7) | | | | | | 1,562 | | | | | | 23,438 | | | | | $ | 22.53 | | | | | | 7/16/2030 | | | | | | | | | | | | | | |
| | | | | 6/30/2020(9) | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 25,000 | | | | | | 743,250 | | |
Murray Stewart, D.M.,
F.R.C.P. |
| | | | 10/15/2018(6) | | | | | | 50,000 | | | | | | 50,000 | | | | | $ | 26.54 | | | | | | 10/14/2028 | | | | | | | | | | | | | | |
| | | | | 2/13/2019(7) | | | | | | 26,250 | | | | | | 33,750 | | | | | $ | 29.78 | | | | | | 2/12/2029 | | | | | | | | | | | | | | |
| | | | | 2/14/2020(7) | | | | | | 16,500 | | | | | | 71,500 | | | | | $ | 17.87 | | | | | | 2/13/2030 | | | | | | | | | | | | | | |
| | | | | 6/30/2020(9) | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 25,000 | | | | | | 743,250 | | |
Jennifer Chien
|
| | | | 11/9/2020(8) | | | | | | — | | | | | | 100,000 | | | | | $ | 24.29 | | | | | | 11/08/2030 | | | | | | | | | | | | | | |
Nithya Desikan
|
| | | | 7/23/2017 | | | | | | 48,201 | | | | | | — | | | | | $ | 6.88 | | | | | | 8/8/2027 | | | | | | | | | | | | | | |
| | | | | 2/14/2018 | | | | | | 38,125 | | | | | | — | | | | | $ | 25.79 | | | | | | 2/13/2028 | | | | | | | | | | | | | | |
| | | | | 2/13/2019 | | | | | | 26,250 | | | | | | — | | | | | $ | 29.78 | | | | | | 2/12/2029 | | | | | | | | | | | | | | |
| | | | | 2/14/2020 | | | | | | 10,000 | | | | | | — | | | | | $ | 17.87 | | | | | | 2/13/2030 | | | | | | | | | | | | | | |
Fee Category
|
| |
2019
|
| |
2020
|
| ||||||
Audit Fees
|
| | | $ | 575,100 | | | | | $ | 813,700 | | |
Audit Related Fees
|
| | | | — | | | | | | — | | |
Tax Fees
|
| | | $ | 32,500 | | | | | $ | 22,500 | | |
All Other Fees
|
| | | $ | 3,345 | | | | | $ | 3,600 | | |
Total Fees
|
| | | $ | 610,945 | | | | | $ | 839,800 | | |
Name and Address of Beneficial Owner
|
| |
Number of Shares
Beneficially Owned† |
| |
Percentage of Shares
Beneficially Owned |
| ||||||
5% or Greater Stockholders: | | | | | | | | | | | | | |
Entities affiliated with PRIMECAP Management Company(1)
|
| | | | 5,570,691 | | | | | | 11.1 | | |
77 E. Colorado Blvd., 11th Floor
Pasadena, CA 91105 |
| | | | | | | | | | | | |
Entities affiliated with New Enterprise Associates 13, L.P.(2)
|
| | | | 4,912,306 | | | | | | 9.8 | | |
New Enterprise Associates
1954 Greenspring Drive, Suite 600 Timonium, MD 21093 |
| | | | | | | | | | | | |
Janus Henderson Group plc(3)
|
| | | | 4,491,765 | | | | | | 8.9 | | |
201 Bishopsgate EC2M 3AE
United Kingdom |
| | | | | | | | | | | | |
Entities affiliated with RA Capital Management, LLC(4)
|
| | | | 4,179,067 | | | | | | 8.3 | | |
c/o RA Capital Management, LLC
200 Berkeley Street, 18th Floor, Boston, MA 02116 |
| | | | | | | | | | | | |
BlackRock, Inc.(5)
|
| | | | 2,731,106 | | | | | | 5.4 | | |
55 East 52nd Street
New York, NY 10055 |
| | | | | | | | | | | | |
Entities affiliated with Deerfield Partners, L.P.(6)
|
| | | | 2,721,203 | | | | | | 5.4 | | |
780 Third Avenue, 37th Floor
New York, NY 10017 |
| | | | | | | | | | | | |
Entities affiliated with Federated Hermes, Inc.(7)
|
| | | | 2,617,600 | | | | | | 5.2 | | |
1001 Liberty Avenue
Pittsburgh, PA 15222-3779 |
| | | | | | | | | | | | |
Directors and Named Executive Officers: | | | | | | | | | | | | | |
David P. Meeker, M.D.(8)
|
| | | | 259,136 | | | | | | * | | |
Keith M. Gottesdiener, M.D.(9)
|
| | | | 1,103,682 | | | | | | 2.2 | | |
Hunter C. Smith(10)
|
| | | | 316,102 | | | | | | * | | |
Murray Stewart, D.M., F.R.C.P. (11)
|
| | | | 127,265 | | | | | | * | | |
Nithya Desikan(12)
|
| | | | 29,068 | | | | | | * | | |
Jennifer Chien(13)
|
| | | | 3,046 | | | | | | * | | |
Stuart A. Arbuckle (14)
|
| | | | 10,000 | | | | | | * | | |
Camille L. Bedrosian, M.D.
|
| | | | — | | | | | | — | | |
Todd Foley(15)
|
| | | | 934,258 | | | | | | 1.9 | | |
Name and Address of Beneficial Owner
|
| |
Number of Shares
Beneficially Owned† |
| |
Percentage of Shares
Beneficially Owned |
| ||||||
Jennifer Good(16)
|
| | | | 10,000 | | | | | | * | | |
Christophe R. Jean(17)
|
| | | | 25,000 | | | | | | * | | |
Edward T. Mathers(18)
|
| | | | 25,000 | | | | | | * | | |
David W.J. McGirr(19)
|
| | | | 112,241 | | | | | | * | | |
Lynn A. Tetrault, J.D.
|
| | | | — | | | | | | — | | |
All executive officers and directors as a group (14 persons)(20)
|
| | | | 3,052,423 | | | | | | 5.9 | | |
| | | | By Order of the Board of Directors | |
| | | |
/s/ David P. Meeker, M.D.
David P. Meeker, M.D.
Chairman of the Board, President and Chief Executive Officer April 27, 2021 |
|